RanBP1在细胞分裂以及肿瘤发生中的作用

Ran-binding protein-1, RanBP1, is one of the key regulators of the Ran GTPase network. RanBP1 is found in all species and the amino acid sequences are highly homologous, containing the Ran binding domain. RanBP1 plays critical roles in multiple cellular processes including nucleocytoplasmic transport, centrosome cohesion, microtubule polymerization, mitotic spindle assembly and cell apoptosis. The misexpression of RanBP1 ultimately affects the accuracy of chromosome segregation, which leads to abnormal cell division and even the occurrence of tumor. RanBP1 was found aberrant expression in many cancers, which attracted the attention of many researchers. This article reviews the role of RanBP1 in cell division and tumor generation.