初步探索基于聚苯胺修饰的金纳米棒的高效光学相干层析成像

Optical coherence tomography (OCT) imaging using contrast agent is a useful technique to improve the contrast effect. Polyaniline (PANI) nanoparticles, an organic conducting polymer, exhibit strong near-infrared absorbance. Herein, we adopted PANI as the shell material for coating gold nanorods (GNRs). To investigate the contrast effect of PANI-functionalized GNRs, we have synthesized three different kinds of nanoparticles containing polyaniline (PANI) nanopartcles, GNRs and PANI/GNRs nanocomposites. They were used as potential OCT contrast agents due to their similar optical properties that they exhibit strong light absorption in near-infrared region. OCT imaging in ex vivo pig liver tissues with the three kinds of nanoparticles was studied. The experimental results indicated that the penetration depth of the signals from pig liver tissues with nanoparticles was significant lower than that from pig liver tissues without nanoparticles. Moreover, in comparison to the bare GNRs, PANI functionalized GNRs exhibited better OCT contrast effect.