Modern human origins: multiregional evolution of autosomes and East Asia origin of Y and mtDNA
Modern human origins: multiregional evolution of autosomes and East Asia origin of Y and mtDNA
Abstract Recent studies have established that genetic diversities are mostly maintained by selection, therefore rendering the present molecular model of human origins untenable. Using improved methods and public data, we have revisited human evolution and derived an age of 1.91-1.96 million years for the first split in modern human autosomes. We found evidence of modern Y and mtDNA originating in East Asia and dispersing via hybridization with archaic humans. Analyses of autosomes, Y and mtDNA all suggest that Denisovan and Neanderthal were archaic Africans with Eurasian admixtures and ancestors of South Asia Negritos and Aboriginal Australians. Verifying our model, we found more ancestry of Southern Chinese from Hunan in Africans relative to other East Asian groups examined. These results suggest multiregional evolution of autosomes and replacements of archaic Y and mtDNA by modern ones originating in East Asia, thereby leading to a coherent account of modern human origins.
Gui Yuanyuan、Yu Jun、Wang Dapeng、Yuan Dejian、Lei Xiaoyun、Huang Shi、Zhu Zuobin
State Key Laboratory of Medical Genetics, School of Life Sciences, Xiangya Medical School, Central South UniversityCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of SciencesCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of SciencesState Key Laboratory of Medical Genetics, School of Life Sciences, Xiangya Medical School, Central South UniversityState Key Laboratory of Medical Genetics, School of Life Sciences, Xiangya Medical School, Central South UniversityState Key Laboratory of Medical Genetics, School of Life Sciences, Xiangya Medical School, Central South UniversityDepartment of Genetics, Xuzhou Medical University
人类学遗传学古生物学
MultiregionalOut-of-AfricaNeutral theorymaximum genetic diversity (MGD) hypothesisNeanderthalsDenisovansHeidelbergensisAboriginal AustraliansNegritos
Gui Yuanyuan,Yu Jun,Wang Dapeng,Yuan Dejian,Lei Xiaoyun,Huang Shi,Zhu Zuobin.Modern human origins: multiregional evolution of autosomes and East Asia origin of Y and mtDNA[EB/OL].(2025-03-28)[2025-04-28].https://www.biorxiv.org/content/10.1101/101410.点此复制
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