Integrating genomics into clinical pediatric oncology using the molecular tumor board at the Memorial Sloan Kettering Cancer Center
Integrating genomics into clinical pediatric oncology using the molecular tumor board at the Memorial Sloan Kettering Cancer Center
Abstract BackgroundPediatric oncologists have begun to leverage tumor genetic profiling to match patients with targeted therapies. At the Memorial Sloan Kettering Cancer Center (MSKCC), we developed the Pediatric Molecular Tumor Board (PMTB) to track, integrate, and interpret clinical genomic profiling and potential targeted therapeutic recommendations. ProcedureThis retrospective case series includes all patients reviewed by the MSKCC PMTB from July 2014 to June 2015. Cases were submitted by treating oncologists and potential treatment recommendations were based upon the modified guidelines of the Oxford Centre for Evidence Based Medicine. ResultsThere were 41 presentations of 39 individual patients during the study period. Gliomas, acute myeloid leukemia, and neuroblastoma were the most commonly reviewed cases. Thirty nine (87%) of the 45 molecular sequencing profiles utilized hybrid-capture targeted genome sequencing. In 30 (73%) of the 41 presentations, the PMTB provided therapeutic recommendations, of which 19 (46%) were implemented. Twenty-one (70%) of the recommendations involved targeted therapies. Three (14%) targeted therapy recommendations had published evidence to support the proposed recommendations (evidence levels 1-2), 8 (36%) recommendations had preclinical evidence (level 3), and 11 (50%) recommendations were based upon hypothetical biological rationales (level 4). ConclusionsThe MSKCC PMTB enabled a clinically relevant interpretation of genomic profiling. Effective use of clinical genomics is anticipated to require new and improved tools to ascribe pathogenic significance and therapeutic actionability. Development of specific rule-driven clinical protocols will be needed for the incorporation and evaluation of genomic and molecular profiling in interventional prospective clinical trials. MSKCCMemorial Sloan Kettering Cancer CenterPMTBPediatric Molecular Tumor BoardALLAcute lymphoblastic leukemiaDSRCTDesmoplastic small round cell tumorAMLAcute myeloid leukemia
Kobos Rachel、Walsh Michael、Slotkin Emily K.、Berger Michael F.、Solit David、Ladanyi Marc、Hameed Meera、Ortiz Michael V.、Roberts Stephen、Shukla Neerav、Kentsis Alex
Department of Pediatrics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center||Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center||Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterHuman Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center||Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center||Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
肿瘤学医学研究方法临床医学
Pediatric oncologyMolecular biologyNew agentsCancer pharmacology
Kobos Rachel,Walsh Michael,Slotkin Emily K.,Berger Michael F.,Solit David,Ladanyi Marc,Hameed Meera,Ortiz Michael V.,Roberts Stephen,Shukla Neerav,Kentsis Alex.Integrating genomics into clinical pediatric oncology using the molecular tumor board at the Memorial Sloan Kettering Cancer Center[EB/OL].(2025-03-28)[2025-06-21].https://www.biorxiv.org/content/10.1101/040584.点此复制
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