离子液体溶解法制备高强度血管用胶原膜材料

Vascular membrane materials with high strength were prepared through an ionic liquid dissolving method. Ionic liquid (1-Butyl-3-methylimidazolium chloride) was used to dissolve collagen, and then the collagen was modified with heparin to prepare high strength films, which were used as vessel graft. The as-prepared collagen-heparin film had excellent elasticity and tensile strength. SEM observations suggested that the prepared film has a porous structure. Cell viability assay indicated that the film facilitated the cell proliferation. Blood compatibility test showed that with the increase of heparin content, APTT was significantly increased while the number of platelet ashesion on the film decreased. This result indicated that modification of collagen with heparin effectively improved the blood compatibility of the film. In summary, heparin-collagen film prepared by ionic liquid dissolving method have strong potential in the field of tissue engineering.