肉桂的化学成分研究

Purpose: Studies on chemical constituents from the bark of Cinnamomum Cassia. Methods: Cinnamomum cassia bark was subjected to reflux extraction using a 60% ethanol-water solution. The resulting extract was further partitioned using dichloromethane and ethyl acetate. The extraction part is separated and purified using modern chromatographic methods such as silica gel column chromatography, ODS column chromatography, and high performance liquid chromatography to obtain monomer compounds. Finally, the isolated compounds were structurally characterized using MS and NMR techniques. Results: Six compounds were isolated from the bark of Cinnamomum Cassia, including three sesquiterpenes and three lignans. Dihydrophaseic acid (1)、2,4-Pentadienoic acid (2)、Bullatantriol (3)、Threo guaiacylglycerol-8-vanillic acid (4)、Erythro guaiacylglycerol-8-vanillic acid (5)、1,2-Ethanedio (6). Conclusion: Compound 1 was isolated from Cinnamomum Cassia for the first time, and compounds 2, 3, 4, 5, 6 were isolated from Cinnamomum for the first time.