龙眼果肉多糖对巨噬细胞活化作用的研究

In this paper effect of the polysaccharide(LP3) purified from longan pulp on macrophages were investigated. The results showed that LP3 could facilitated the proliferation and enhance the phagocytosis of macrophage in a certain concentration range. The proliferation and phagocytosis of macrophages exposed to 400 μg/mL LP3 were135.90% and 192.03%, repectively. LP3could improve the secretion of NO, TNF-α and IL-6 in a dose dependent manner. The NO secretion secreted by macrophages stimulated by 200 μg/mL LP3 was 5.4 times than that of the control group. The TNF-α and IL-6 production of macrophages exposed to 400 μg/mL LP3 were 296.20 pg/mL and 73.69 pg/mL, which were 17.67times and 18.42 times than that of the blank group, respectively. All these results demonstrated that LP3 could activated the macrophages and regulate its functions.