α-淀粉酶抑制剂（白芸豆提取物）对2型糖尿病患者生理代谢及肠道菌群的影响

Based on diabetes diet education, blood glucose monitoring and other comprehensive intervention, the α-AI extract of white kidney bean was added to dietary of type 2 diabetes patients. Its effect on the physiological and metabolic indicators of type 2 diabetes were studied, and the mechanism of white kidney bean α-ai extract in vivo by studying the changes of its intestinal flora have been reaveled.The results showed that the blood glucose was well controlled after the intervention of white kidney bean α-AI extract, and the glycosylated hemoglobin (HbA1c), fasting blood glucose and postprandial blood glucose were significantly decreased. The decrease of low-density lipoprotein (LDL-c) was significantly larger than that of the control group, on the contrary, the increase of high-density lipoprotein (HDL-c) was significantly larger than that of the control group. The diabetic complications also were improved after eating white kidney bean α-AI extract. After eating white kidney bean extract, the absorption of starch in the digestive system was reduced, so that more starch to the large intestine. Compared to 4 months intervention, the change of structure of intestinal flora was more significant foe 2 months intervention. The α- diversity of flora did not change significantly before and after intervention, and the diversity β- flora was significantly different compared with the control (2 months of intervention ,4 months of p<0.05; intervention, p<0.01). After adding white kidney bean extract 2 months, Bifidobacterium, Faecalibacterium and other beneficial bacteria wrere significantly enriched, and the abundance of Escherichia / Shigella, which is generally considered to contain potential opportunistic bacteria, were reduced. However, only Bifidobacterium was significantly enriched at 4 months. .