针刺对营养性肥胖大鼠下丘脑SOCS3 mRNA表达的影响

IM:To research the effects of Specific Acupuncture on losing weight, and its mechanism of regulating serum insulin and the hypothalamus SOCS3 mRNA Expression. METHODS: The obese rats were copied by Nutritional Obesity molding methods, and were treated from the sixth to the thirteenth week of the experiment. The body weight,body length, Lee's index of obesity, FBG, TG, Cholesterol, HDL, LDL and Insulin were observed and measured before and after acupuncture treatment. The hypothalamus SOCS3 mRNA Expression was tested by RT-PCR.RESULTS: At the sixth week, the body weight,body le ngth, Lee's index of obesity of the nutritional obese rats were obviously higher than the ordinary provender group. The blood biochemistry, such as FBG, TG, Cholesterol, LDL and Insulin were higher than the ordinary provender group,except that the HDL was lower. Furthermore, the hypothalamus SOCS3 mRNA Expression had obvious increased. At the thirteenth week, the body weight, body length, Lee's index of obesity, FBG, TG, Cholesterol, HDL, LDL, Insulin and the hypothalamus SOCS3 mRNA Expression of the model group were obviously higher than the ordinary provender group. And the body weight, body length, Lee's index of obesity, FBG, TG, Cholesterol, LDL, Insulin and the hypothalamus SOCS3 mRNA Expression of the acupuncture group were markedly lower than the model group, except that the HDL was higher. CONCLUSION: The Specific Acupuncture points of Zhongwan, zusa li could work well on losing weight. Its mechanism may be related to down-regulate the expression of SOCS3 mRNA in hypothalamus and counteract the insulin and leptin.