The RacGAP βChimaerin is essential for cerebellar granule cell migration
The RacGAP βChimaerin is essential for cerebellar granule cell migration
Abstract During mammalian cerebellar development, postnatal granule cell progenitors proliferate in the outer part of the External Granule Layer (EGL). Postmitotic granule progenitors migrate tangentially in the inner EGL before switching to migrate radially inward, past the Purkinje cell layer, to achieve their final position in the mature Granule Cell Layer (GCL). Here, we show that the RacGAP β-chimaerin is expressed by a small population of late-born, premigratory granule cells. β-chimaerin deficiency causes a subset of granule cells to become arrested in the EGL, where they differentiate and form ectopic neuronal clusters. These clusters of granule cells are able to recruit aberrantly projecting mossy fibers. Collectively, these data suggest a role for β-chimaerin as an intracellular mediator of Cerebellar Granule Cell radial migration.
Wong Wenny、Estep Jason A.、Loui Brian M.、Riccomagno Martin M.、Wong Yiu-Cheung E.
Neuroscience Program, Department of Molecular, Cell, and Systems Biology, University of CaliforniaCell, Molecular and Developmental Biology Program, Department of Molecular, Cell, and Systems Biology, University of CaliforniaNeuroscience Program, Department of Molecular, Cell, and Systems Biology, University of CaliforniaCell, Molecular and Developmental Biology Program, Department of Molecular, Cell, and Systems Biology, University of California||Neuroscience Program, Department of Molecular, Cell, and Systems Biology, University of CaliforniaNeuroscience Program, Department of Molecular, Cell, and Systems Biology, University of California
细胞生物学分子生物学生理学
neuronal migrationcerebellumRacGAPchimaeringranule cells
Wong Wenny,Estep Jason A.,Loui Brian M.,Riccomagno Martin M.,Wong Yiu-Cheung E..The RacGAP βChimaerin is essential for cerebellar granule cell migration[EB/OL].(2025-03-28)[2025-06-20].https://www.biorxiv.org/content/10.1101/164897.点此复制
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