银介导的3,3-二取代吲哚-2-酮衍生物的合成

Indol-2-one and its derivatives are common pharmaceutical intermediates with interesting chemical properties and great medicinal value. Therefore, the rapid, efficient and precise synthesis of their derivatives has attracted increasing attention of scientists. This paper reports the addition-cyclization reaction of silver one-electron reduction of bromocarboxylate to form α-carbonyl radical and N-phenylacrylamide, and a series of 3,3-disubstituted indol-2-ones were synthesized. compound. By screening the reaction conditions, such as silver salt, solvent, reaction temperature and time, the optimal reaction conditions were obtained, and 43 functionalized 3,3-disubstituted indol-2-one derivatives were successfully prepared. The yield is as high as 97%. The method is easy to operate and has good tolerance to common functional groups.