尾状核−眶部内侧前额叶的功能连接与反应性攻击的关系：基于静息态功能磁共振研究
采用修改后的Taylor攻击范式, 将被试为虚拟对手选择的白噪音的惩罚强度作为反应性攻击的指标, 选取眶部内侧前额叶(Orbitomedial Prefrontal Cortex, OMPFC)作为种子点, 考察静息状态下正常人群OMPFC与其他脑区的连接及其与反应性攻击之间的关系。功能连接结果表明, 左侧OMPFC与右侧角回(Angular gyrus)、左侧OMPFC与双侧尾状核(Caudate nucleus)、右侧OMPFC与右侧尾状核的功能连接与反应性攻击显著负相关。格兰杰因果分析的结果进一步表明, 右侧尾状核到右侧OMPFC的效应连接与反应性攻击呈显著负相关, 尤其是与激发条件下的反应性攻击呈显著负相关。这表明, 静息状态下OMPFC与尾状核的连接与反应性攻击有着密切的关系。
Reactive aggression has been widely concerned by researchers because of its serious impact on society, such as violent crimes. Existing neuroimaging studies using patients with high levels of aggression indicated a network of brain regions subserve reactive aggression, including amygdala, caudate nucleus, and orbitofrontal cortex. Furthermore, researchers believed that reduced prefrontal activity along with heightened subcortical activity in the context of provocative stimuli poses an increased risk for reactive aggression. However, evidence for this theory in healthy population is lacking, especially this independently of the experiment task.
邱江、李长燃、江 琦、王焕贞、侯璐璐
神经病学、精神病学基础医学医学研究方法
反应性攻击静息态功能磁共振功能连接效应连接格兰杰因果分析眶部内侧前额叶尾状核
邱江,李长燃,江 琦,王焕贞,侯璐璐.尾状核−眶部内侧前额叶的功能连接与反应性攻击的关系：基于静息态功能磁共振研究[EB/OL].(2018-03-22)[2025-08-06].https://chinaxiv.org/abs/201803.01125.点此复制
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