Can malaria parasites manipulate the odour-mediated host preference of their mosquito vectors?
Can malaria parasites manipulate the odour-mediated host preference of their mosquito vectors?
Abstract Malaria parasites can manipulate mosquito feeding behaviours such as motivation and avidity to feed on vertebrate hosts in ways that increase parasite transmission. However, in natural conditions, not all vertebrate blood-sources are suitable hosts for the parasite. Whether malaria parasites can manipulate mosquito host choice in ways that enhance parasite transmission toward suitable hosts and/or reduce mosquito attraction to unsuitable hosts (i.e. specific manipulation) is unknown. To address this question, we experimentally infected three species of mosquito vectors (Anopheles coluzzii, Anopheles gambiae, and Anopheles arabiensis) with wild isolates of the human malaria parasite Plasmodium falciparum, and examined the effects of immature (oocyst) and mature (sporozoite) infections on mosquito behavioural responses (activation rate and odour choice) to combinations of calf odour, human odour and outdoor air using a dual-port olfactometer. Regardless of parasite developmental stage and mosquito species, P. falciparum infection did not alter mosquito activation rate or their choice for human odours. The overall expression pattern of host choice of all three mosquito species was consistent with a high degree of anthropophily, with both infected and uninfected individuals showing higher attraction toward human odour over calf odour, human odour over outdoor air, and outdoor air over calf odour. Our results suggests that, in this system, the parasite may not be able to manipulate the early long-range behavioural steps involved in the mosquito host-feeding process, including initiation of host-seeking and host orientation. Future studies examining mosquito host-feeding behaviours at a shorter range (i.e. the “at-host” foraging activities) are required to test whether malaria parasites can modify their mosquito host choice to enhance transmission toward suitable hosts and/or reduce biting on unsuitable hosts.
Hien Domonbabele FdS、Gouagna Louis-Cl¨|ment、Fontenille Didier、Simard Fr¨|d¨|ric、Costantini Carlo、Cohuet Anna、Thomas Fr¨|deric、Yameogo Bienvenue K.、Dabir¨| Kounbobr R.、Vantaux Am¨|lie、Lef¨¨vre Thierry、Nguyen Phuong L.、Renaud Fran?ois
Institut de Recherche en Sciences de la Sant¨| (IRSS)MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, G¨|n¨|tique, Evolution et Contr?le)MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, G¨|n¨|tique, Evolution et Contr?le)||Institut Pasteur du CambodgeMIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, G¨|n¨|tique, Evolution et Contr?le)MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, G¨|n¨|tique, Evolution et Contr?le)MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, G¨|n¨|tique, Evolution et Contr?le)MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, G¨|n¨|tique, Evolution et Contr?le)Institut de Recherche en Sciences de la Sant¨| (IRSS)Institut de Recherche en Sciences de la Sant¨| (IRSS)||Laboratoire mixte international sur les vecteurs (LAMIVECT)MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, G¨|n¨|tique, Evolution et Contr?le)||Institut de Recherche en Sciences de la Sant¨| (IRSS)MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, G¨|n¨|tique, Evolution et Contr?le)||Institut de Recherche en Sciences de la Sant¨| (IRSS)||Laboratoire mixte international sur les vecteurs (LAMIVECT)MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, G¨|n¨|tique, Evolution et Contr?le)MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, G¨|n¨|tique, Evolution et Contr?le)
医学研究方法基础医学昆虫学
Anophelesexperimental infectionhost manipulation by parasiteshost-seeking behavioursolfactometerPlasmodium
Hien Domonbabele FdS,Gouagna Louis-Cl¨|ment,Fontenille Didier,Simard Fr¨|d¨|ric,Costantini Carlo,Cohuet Anna,Thomas Fr¨|deric,Yameogo Bienvenue K.,Dabir¨| Kounbobr R.,Vantaux Am¨|lie,Lef¨¨vre Thierry,Nguyen Phuong L.,Renaud Fran?ois.Can malaria parasites manipulate the odour-mediated host preference of their mosquito vectors?[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/114272.点此复制
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