食用三聚氰胺污染奶粉的婴幼儿生长发育与泌尿系结石的三年随访研究

Objective: To investigate the long-term effect of melamine tainted milk powder on the growth and development of infants and young children through 3 years follow-up. Methods: The clinical data of the 40 months follow-up of the 98 infants and young children with an average age of 68.7±9.4 months old were retrospectively reviewed. The melamine-related urinary stones (MUS) were formed by melamine-tainted milk feeding. Urinary tract ultrasonography, urinalysis and blood biochemistry including renal and liver function tests were performed during follow-up. Ninety age (age: 69.2±9.2 months) and gender matched health individuals were chosen as controls. Results: Eighty-six cases were followed-up successfully. Sixty-seven children had residual MUS at the time of discharge. After 3 years follow-up, MUS in 64 patients disappeared completely and in 3 patients remained the same size. No urology tumors were detected during follow-up. The weight, height and head circumference in infants and young children with MUS are lower than control groups. Blood routine and urinalysis as well as function and morphology of urinary system showed no obvious abnormalities. Conclusion: Melamine-tainted milk powder influences the growth and development of the infants and young children, but no significant negative effect is found in liver and renal function.