一种合成脂肪族取代的1,2,3-三氮唑类化合物的新方法

1,2,3-Trizaole derivatives have been widely used in the fields of medicine, pesticide, and materials. Thus, much attention have been paid to the synthesis of various 1,2,3-trizaole derivatives. However, the function group transformation of 1,2,3-triazole derivatives was less studied. In this manuscript, in the presence of base and copper salt as the catalysts, the sulfonyl group of 1,2,3-triazole derivatives could be transformed to other function groups in a "one-pot two-steps" manner, including benzyl, substituted benzyl, halide substituted alkyl or alkyl groups. This me-thod exhibited mild reaction conditions, simple operation, good selectivity and low catalyst loading. Meanwhile, based the captured reaction intermediate, the reaction mechanism also was proposed.