Decrease in multiple complement protein levels is associated with the development of islet autoimmunity and type 1 diabetes
Decrease in multiple complement protein levels is associated with the development of islet autoimmunity and type 1 diabetes
Summary Type 1 diabetes (T1D) is a chronic condition caused by autoimmune destruction of the insulin-producing pancreatic β-cells. While it is known that gene-environment interactions play a key role in triggering the autoimmune process leading to T1D, the pathogenic mechanism leading to the appearance of islet autoantibodies - biomarkers of autoimmunity – is poorly understood. Here we show that disruption of the complement system precedes the detection of islet autoantibodies and persists through disease onset. Our results suggest that children who exhibit islet autoimmunity and progress to clinical T1D have lower complement protein levels relative to those who do not progress within a similar timeframe. Thus, the complement pathway, an understudied mechanistic and therapeutic target in T1D, merits increased attention for use as protein biomarkers of prediction and potentially prevention of T1D.
Rewers Marian J、Holers V. Michael、Nakayasu Ernesto S、Dong Fran、Schepmoes Athena、Onengut-Gumuscu Suna、Metz Thomas O、Gao Yuqian、Rich Stephen S、Fillmore Thomas、Flores Javier、Frazer-Abel Ashley、Webb-Robertson Bobbie-Jo M、Waugh Kathy C、Bramer Lisa M
Barbara Davis Center for Diabetes, School of Medicine, University of Colorado Anschutz Medical CampusDivison of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical CampusBiological Sciences Division, Pacific Northwest National LaboratoryBarbara Davis Center for Diabetes, School of Medicine, University of Colorado Anschutz Medical CampusBiological Sciences Division, Pacific Northwest National LaboratoryCenter for Public Health Genomics, University of VirginiaBiological Sciences Division, Pacific Northwest National LaboratoryBiological Sciences Division, Pacific Northwest National LaboratoryCenter for Public Health Genomics, University of VirginiaBiological Sciences Division, Pacific Northwest National LaboratoryBiological Sciences Division, Pacific Northwest National LaboratoryDivison of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical CampusBiological Sciences Division, Pacific Northwest National Laboratory||Colorado School of Public Health, University of Colorado Anschutz Medical Campus||Department of Pathology, Immunology and Laboratory Medicine, University of Florida||Department of Biomedical Engineering, Oregon Health & Science UniversityBarbara Davis Center for Diabetes, School of Medicine, University of Colorado Anschutz Medical CampusBiological Sciences Division, Pacific Northwest National Laboratory
医药卫生理论基础医学临床医学
Type 1 diabetesautoimmune diseaseproteomicsbiomarkerscomplement system
Rewers Marian J,Holers V. Michael,Nakayasu Ernesto S,Dong Fran,Schepmoes Athena,Onengut-Gumuscu Suna,Metz Thomas O,Gao Yuqian,Rich Stephen S,Fillmore Thomas,Flores Javier,Frazer-Abel Ashley,Webb-Robertson Bobbie-Jo M,Waugh Kathy C,Bramer Lisa M.Decrease in multiple complement protein levels is associated with the development of islet autoimmunity and type 1 diabetes[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2023.07.13.23292628.点此复制
评论