紧密粘连蛋白的研究进展

Zonula occludens (ZO) proteins are vital scaffold proteins of tight junction and link integral membrane proteins to the actin cytoskeleton. As members of the membrane associated guanylate kinase-like protein family, ZO proteins contain many specific domains that directly combine with diverse transmembrane and cytoplasmic proteins. Many extracellular and intracellular stimuli can affect ZO proteins expression, distribution, phosphorylation, and the combination with other proteins through multiple signaling pathways. Here we summarize recent studies on the role of ZO proteins in tight junction.