SARS-CoV-2 virus dynamics in recently infected people – data from a household transmission study
SARS-CoV-2 virus dynamics in recently infected people – data from a household transmission study
Abstract We used daily real-time reverse-transcription polymerase chain reaction (rRT-PCR) results from 67 cases of SARS-CoV-2 infection in a household transmission study to examine the trajectory of cycle threshold (Ct) values, an inverse correlate of viral RNA concentration, from nasal specimens collected between April 2020 and May 2021. Ct values varied over the course of infection, across RT-PCR platforms, and by participant age. Specimens collected from children and adolescents showed higher Ct values and adults aged ≥50 years showed lower Ct values than adults aged 18-49 years. Ct values were lower on days when participants reported experiencing symptoms.
Hanson Kayla E.、Zhu Yuwei、Deyoe Jessica、Reed Carrie、Halasa Natasha B.、Grijalva Carlos G.、Ivacic Lynn C.、Meece Jennifer K、Mellis Alexandra M.、McLean Huong Q.、Rolfes Melissa A.、Kim Ahra、Chappell James D.、Talbot H. Keipp
Marshfield Clinic Research InstituteVanderbilt University Medical CenterCenters for Disease Control and PreventionCenters for Disease Control and PreventionVanderbilt University Medical CenterVanderbilt University Medical CenterMarshfield Clinic Research InstituteMarshfield Clinic Research InstituteCenters for Disease Control and PreventionMarshfield Clinic Research InstituteCenters for Disease Control and PreventionVanderbilt University Medical CenterVanderbilt University Medical CenterVanderbilt University Medical Center
医学研究方法基础医学微生物学
SARS-CoV-2cycle threshold valuesageviral dynamicsRT-PCR
Hanson Kayla E.,Zhu Yuwei,Deyoe Jessica,Reed Carrie,Halasa Natasha B.,Grijalva Carlos G.,Ivacic Lynn C.,Meece Jennifer K,Mellis Alexandra M.,McLean Huong Q.,Rolfes Melissa A.,Kim Ahra,Chappell James D.,Talbot H. Keipp.SARS-CoV-2 virus dynamics in recently infected people – data from a household transmission study[EB/OL].(2025-03-28)[2025-05-16].https://www.medrxiv.org/content/10.1101/2022.03.17.22272516.点此复制
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