安徽地区不同性别中年肥胖居民甘油三酯葡萄糖乘积(TyG) 指数与心血管疾病高危风险的关系
Relationship between triglyceride glucose product (TyG) index and risk of cardiovascular disease in obese middle-aged residents of different genders in Anhui Province
背景 甘油三酯葡萄糖乘积（TyG）指数是评价胰岛素抵抗（IR）和肥胖相关的代谢性疾病的指标，但该指标与不同性别中年肥胖人群发生心血管疾病（CVD）高危风险的有关研究却尚少。目的 探讨TyG指数与不同性别中年肥胖人群发生CVD高危风险的关系，评估其在CVD防治中的作用。方法 选取安徽省30425名中年（45-60岁）肥胖常住居民作为研究对象，按照不同性别分为男性组和女性组，男性组TyG 指数四分位数分组分为T1（7.420-8.870）、T2（8.870-9.204）、T3（9.204-9.578）、T4（9.578-11.440），女性组分为T1（7.579-8.876）、T2（8.876-9.183）、T3（9.183-9.526）、T4（9.526-11.647）,采用χ2检验分析不同性别人群CVD高危检出情况，建立多因素二元Logistic 回归模型探究TyG 指数与发生CVD高危风险的关系，采用Z检验来比较亚组间的效应值差异。结果 发生CVD高危风险比例在男性组中为28.4%，在女性组中为26.0%。多因素二元 logistic回归模型结果显示，在男性组和女性组中，TyG指数各个四分位数分组均有统计学意义（P<0.01）。与T1相比，在男性组和女性组中，TyG指数T4发生CVD高危的风险[OR(95%CI)]分别为:1.827（1.622，2.058）、1.552（1.410，1.708），男性和女性两组OR值比较，在T4中差异有统计学意义（P<0.05）。再进一步调整了总胆固醇等指标后，TyG指数与发生CVD高危风险的相关性有所减弱，两组中的TyG指数在T2、T3、T4均有统计学意义（P<0.05），且随着TyG指数水平的逐渐升高，其与发生CVD高危风险的相关性逐渐增加。与T1相比，在男性和女性组中，TyG指数T4组发生CVD高危的风险[OR(95%CI)]分别为:1.804（1.584，2.055）、1.496（1.345，1.665），男女两组OR值比较中，在T4中差异有统计学意义（P<0.05）。结论 中年肥胖男性人群高水平的TyG指数更易于发生CVD高危风险，应重点关注该群体的TyG指数水平。
医药卫生理论内科学预防医学
甘油三酯葡萄糖乘积(TyG) 指数不同性别心血管病（CVD）中年肥胖人群CVD高危风险因素
易伟卓,顾怀聪,王为强,韩正,傅方琳,潘姚佳,董雅勤,孙梦.安徽地区不同性别中年肥胖居民甘油三酯葡萄糖乘积(TyG) 指数与心血管疾病高危风险的关系[EB/OL].(2023-01-09)[2025-10-24].https://chinaxiv.org/abs/202301.00091.点此复制
Background Triglyceride glucose product (TyG) index is an index to evaluate insulin resistance (IR) and obesity-related metabolic diseases, but there are few studies on the correlation between this index and the high risk of cardiovascular disease (CVD) in middle-aged obese people of different genders. Objective To investigate the relationship between TyG index and the high risk of CVD in middle-aged obese people of different genders, and to evaluate its role in the prevention and treatment of CVD. Methods A total of 30,425 obese middle-aged (45-60 years old) permanent residents in Anhui Province were selected as research objects and divided into male group and female group according to different gender. Male TyG index was divided into four quartiles: T1 (7.420-8.870), T2 (8.870-9.204), T3 (9.204-9.578), T4 (9.578-11.440). The female group was divided into T1 (7.579-8.876), T2 (8.876-9.183), T3 (9.183-9.526) and T4 (9.526-11.647). χ2 test was used to analyze the detection of CVD risk in different genders. Multivariate binary Logistic regression model was established to explore the relationship between TyG index and the high risk of CVD, and Z-test was used to compare the difference in effect values between subgroups. Result The high risk of CVD was 28.4% in the male group and 26.0% in the female group. The results of multivariate binary logistic regression model showed that in male group and female group, each quartile grouping of TyG index had statistical significance (P<0.01). Compared with T1, the high risk of CVD at TyG index T4 in male group and female group [OR(95%CI)] was 1.827(1.622, 2.058) and 1.552(1.410, 1.708), respectively, and there was a statistically significant difference in the OR values between male and female groups in T4 (P<0.05). After further adjustment of total cholesterol and other indicators, the correlation between TyG index and the high risk of CVD was weakened, and the TyG index in the two groups showed statistical significance at T2, T3 and T4 (P<0.05), and with the gradual increase of TyG index level, the correlation with the high risk of CVD gradually increased. Compared with T1, in male and female groups, the TyG index of high risk of CVD in T4 group [OR(95%CI)] was 1.804(1.584, 2.055) and 1.496(1.345, 1.665), respectively. There was a statistically significant difference in the OR value between male and female groups in T4 (P<0.05). Conclusion Middle-aged obese men with a high level of TyG index are more prone to CVD risk, and the TyG index level of this group should be paid more attention to.
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