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新型染料木素磷酸酯衍生物的合成与表征

Synthesis and character of novel phosphorylated genistein derivatives

中文摘要英文摘要

以染料木素衍生物和亚磷酸酯为原料,采用改进的Atherton-Todd反应在三乙胺和四氯化碳存在下较高收率得到6种染料木素磷酸酯衍生物,产物通过IR、ESI MS和NMR等方法进行了表征。结果发现磷酰化试剂对染料木素及其衍生物羟基的磷酰化具有较好的选择性,反应主要发生在染料木素的7位羟基,其次是4?位羟基,5位羟基不反应。

series of genistein phosphate derivatives were synthesized through a simplified Atherton-Todd reaction using genistein and phosphate as the raw material under the condition of triethylamine and tetrachloromethane, and their structures were determined by IR, ESI Ms and NMR. The result showed that monophosphorylated reaction occur at the 7-position of genistein, but not at its 4-position and 5-position.

郁章琦、屈凌波、李旭、陈晓岚

生物化学制药化学工业染料工业

染料木素磷酰化选择性磷酸酯

genisteinphosphorylationselectivityphosphate

郁章琦,屈凌波,李旭,陈晓岚.新型染料木素磷酸酯衍生物的合成与表征[EB/OL].(2014-03-14)[2025-08-18].http://www.paper.edu.cn/releasepaper/content/201403-480.点此复制

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