多环芳烃暴露对子宫的影响

Polycyclic aromatic hydrocarbons (PAHs) are a large group of toxic substances produced by the incomplete combustion of organic fuels. They are hydrocarbons with two or more benzene rings and are widely present in environment. Because PAHs cause damage to the respiratory, circulatory, reproductive, immune and cardiovascular systems, they have been the focus of national and international toxicologists. Women are highly susceptible to PAHs and their reproductive functions are extremely vulnerable to PAHs. A large body of reported literature suggests that PAHs exposure can produce uterine reproductive toxicity, such as hormonal disruption, abnormal cell proliferation, altered signaling pathways, regulate genes expression and cancer. PAHs can also cross the placental barrier and affect the zygote in the womb. This review summarizes the toxic effects of various PAHs on the uterus reported in the literature in recent years, and provides an in-depth analysis of the hazards of PAHs exposure on the uterus of the current generation and offspring at the molecular toxicology level.