代谢组学技术在毒理学研究中的应用

Metabonomics is a newly developed technology for qualitative and quantitative analysis on all low molecular weight metabolites in cells or organisms in a particular physiological period. Through the analysis and exploration on changes in metabolites from the intervention of poison on the body's physiological and pathological changes using nuclear magnetic resonance and mass spectrometry, the mechanism of toxicity can be identified. This article briefly reviewed the metabonomics technology, the exploration of biomarkers, toxicological mechanisms, drug screening and pre-clinical safety evaluation on drug, food safety evaluation, and issues needed to be paid attention in toxicology studies using metabonomics.