Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder
Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder
ABSTRACT Identifying brain processes involved in the risk and development of mental disorders is a major aim. We recently reported substantial inter-individual heterogeneity in brain structural aberrations among patients with schizophrenia and bipolar disorder. Estimating the normative range of voxel-based morphometry (VBM) data among healthy individuals using a gaussian process regression (GPR) enables us to map individual deviations from the healthy range in unseen datasets. Here we aim to replicate our previous results in two independent samples of patients with schizophrenia (n1=94; n2=105), bipolar disorder (n1=116; n2=61) and healthy individuals (n1=400; n2=312). In line with previous findings with exception of the cerebellum our results revealed robust group level differences between patients and healthy individuals, yet only a small proportion of patients with schizophrenia or bipolar disorder exhibited extreme negative deviations from normality in the same brain regions. These direct replications support that group level-differences in brain structure disguise considerable individual differences in brain aberrations, with important implications for the interpretation and generalization of group-level brain imaging findings to the individual with a mental disorder.
Westlye Lars T、Aln?s Dag、Kia Seyed Mostafa、Zabihi Mariam、Moberget Torgeir、Melle Ingrid、Berthet Pierre、Kaufmann Tobias、Wolfers Thomas、Beckmann Christian F、Rokicki Jaroslav、Agartz Ingrid、Andreassen Ole A、Marquand Andre F
Department of Psychology, University of Oslo||Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, University of Oslo & Oslo University Hospital||KG Jebsen Centre for Neurodevelopmental Disorders, University of OsloDepartment of Psychology, University of Oslo||Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, University of Oslo & Oslo University HospitalDonders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud UniversityDonders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud UniversityDepartment of Psychology, University of Oslo||Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, University of Oslo & Oslo University HospitalNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, University of Oslo & Oslo University HospitalDepartment of Psychology, University of Oslo||Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, University of Oslo & Oslo University HospitalNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, University of Oslo & Oslo University HospitalDepartment of Psychology, University of Oslo||Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, University of Oslo & Oslo University Hospital||Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud UniversityDonders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University||Department of Cognitive Neuroscience, Radboud University Medical CentreDepartment of Psychology, University of Oslo||Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, University of Oslo & Oslo University HospitalNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, University of Oslo & Oslo University Hospital||KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo||Department of Psychiatric Research, Diakonhjemmet Hospital||Centre for psychiatric research, Department of Clinical NeuroscienceNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, University of Oslo & Oslo University Hospital||KG Jebsen Centre for Neurodevelopmental Disorders, University of OsloDonders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University||Department of Cognitive Neuroscience, Radboud University Medical Centre||Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, King?ˉs College London
神经病学、精神病学医学研究方法基础医学
normative modellingmental disordersbrain imagingschizophreniabipolar disorderheterogeneitystructural MRI
Westlye Lars T,Aln?s Dag,Kia Seyed Mostafa,Zabihi Mariam,Moberget Torgeir,Melle Ingrid,Berthet Pierre,Kaufmann Tobias,Wolfers Thomas,Beckmann Christian F,Rokicki Jaroslav,Agartz Ingrid,Andreassen Ole A,Marquand Andre F.Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder[EB/OL].(2025-03-28)[2025-05-16].https://www.medrxiv.org/content/10.1101/2020.05.08.20095091.点此复制
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