28 IVS3 +17T>C 基因多态与宫颈癌患病风险关系的研究

HPV plays a causal role in cervical carcinogenesis. However, only a small portion of infected individuals develop cervical cancer. Host genetic factors may confer susceptibility to this disease. CD28 participate in the maintenance of immune homeostasis as an important positive co-stimulatory molecule. Allelic variation of immuno-modulatory genes may be associated with alteration in immune function. This study is to investigate the associations between CD28 IVS3 +17T>C polymorphisms and risk of cervical cancer in Chinese population. Genotypes of CD28 polymorphisms were detected in 619 cases with primary cervical cancer and 985 normal controls. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression. A higher frequency of CD28 +17TC heterozygote was determined in patients in comparison with controls (19.4% versus 12.5%). Subjects carrying one CD28 IVS3 +17 C allele ( TC or CC genotype) had increased risk of cervical cancer (OR = 1.66, 95% CI, 1.27 to 2.17). This study suggests that CD28 IVS3 +17T>C polymorphism might be genetic susceptibility factor for cervical cancer in a Chinese population.