表皮葡萄球菌色氨酰-tRNA合成酶抑制剂W-23的抗菌活性研究

Objective: Investigate the antibacterial activity of W23, a new inhibitor of Staphylococcus epidermidis tryptophanyl-tRNA synthetase. Methods: Determine the Minimal Inhibitory Concentration of W-23 to Staphylococcus epidermidis, Staphylococcus aureus and Escherichia coli; detect the effect of W-23 in combination with Ampicillin or Chloramphenicol on S. epidermidis growth. Results: The MIC of W-23 to Staphylococcus species is about 2-4 μg/ml. W-23 is a bacteristatic agent. Combination of W-23 and ampicillin has synergistic effect on growth of methicillin-resistent Staphylococcus epidermidis. Conclusion: W-23 has potent antibacterial activity against Staphylococcus and has a potential value in new drug development.