汉族人群维生素D受体基因Fok I 多态性与特发性早产的相关性
目的 探讨维生素D受体（VDR）基因Fok I位点多态性与早产发生风险的相关性，为临床上治疗和预防先兆早产或早产发 生寻找新途径，改善母婴结局。方法 纳入早产患者57例和足月妊娠分娩患者84例。VDR基因 Fok I位点基因型采用聚合酶 链反应-限制性片断长度多态（PCR-RFLP）法检测基因多态性。结果 早产组与足月妊娠分娩组在血细胞比容（HCT)、D-二聚 体、纤维蛋白原、血清钙、白细胞、糖化血红蛋白间未见明显差异（P>0.05）。早产组VDR基因Fok I基因型分布和F/f等位基因频 率与足月妊娠分娩组相比较，两者间的差异有统计学意义（P0.05）。结论 VDR基因Fok I位点多态性与早产遗传易感性相关，FF基因型可能 是早产发生潜在的高危因素。
Objective To explore the relationship between vitamin D receptor (VDR) gene pol-ymorphisms at Fok I site and the risk of preterm birth for potential intervention of of preterm birth or threatened premature delivery. Methods Fifty-seven women with preterm birth and 84 with full-term birth were included in this analysis. Polymerase chain reaction-restriction frag-ment length polymorphism (PCR-RFLP) was performed to identify VDR gene Fok I geno-types. Results No significant difference was found in age, D-dimer (DDI), fibrinogen (Fg), serum calcium (Ca2 + ), leukocyte count or glycosylated hemoglobin (HbA1c) level between the women in the preterm and full-term birth groups (P>0.05). The two groups differed signifi-cantly in the distribution of VDR gene Fok I site genotypes and allele frequency of F/F (P0.05). Conclusion VDR gene Fok I site geno-types are related with preterm birth, and the FF genotype may serveasapotentialriskfactorforpretermbirth.
朱宝平、沈小雅、潘石蕾、蔡蔚
基础医学妇产科学
早产维生素D受体基因Fok I多态性
朱宝平,沈小雅,潘石蕾,蔡蔚.汉族人群维生素D受体基因Fok I 多态性与特发性早产的相关性[EB/OL].(2018-01-25)[2025-08-02].https://chinaxiv.org/abs/201801.00660.点此复制
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