Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection
Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection
Abstract Brazil, which is hyperendemic for dengue virus (DENV), has had recent Zika (ZIKV) and (CHIKV) Chikungunya virus outbreaks. Since March 2016, CHIKV is the arbovirus infection most frequently diagnosed in Rio de Janeiro. In the analysis of 1835 syndromic patients, screened by real time RT-PCR, 56.4% of the cases were attributed to CHIKV, 29.6% to ZIKV, and 14.1% to DENV-4. Sequence analyses of CHIKV from sixteen samples revealed that the East-Central-South-African (ECSA) genotype of CHIKV has been circulating in Brazil since 2013 [95% bayesian credible interval (BCI): 03/2012-10/2013], almost a year before it was detected by arbovirus surveillance program. Brazilian cases are related to Central African Republic sequences from 1980’s. To the best of our knowledge, given the available sequence published here and elsewhere, the ECSA genotype was likely introduced to Rio de Janeiro early on 2014 (02/2014; BCI: 07/2013-08/2014) through a single event, after primary circulation in the Bahia state at the Northestern Brazil in the previous year. The observation that the ECSA genotype of CHIKV was circulating undetected underscores the need for improvements in molecular methods for viral surveillance.
Vieira Yasmine Rangel、Vizzoni Alexandre、Jain Komal、Mesquita Milene、Bhuva Nishit、Monteiro Ana Paula Teixeira、Leomil Luciana、Torres Maria C.、Thompson Fabiano L.、Durovni Betina、Morel Carlos M.、Lipkin W. Ian、Mishra Nischay、Lemos Cristina、Cerbino-Neto Jos¨|、Thakkar Riddhi、Calheiros Andrea Surrage、de Filippis Ana Maria Bispo、Souza Thiago Moreno L.、Tschoeke Diogo A.、Ng James、Delatorre Edson、Bozza Patr¨acia T.、de Mendon?a Marcos Cesar Lima、dos Santos Rodrigues Cintia Damasceno、Nogueira Rita Maria Ribeiro、Luiz Raul Leal Faria、Bozza Fernando A.、Gogarten Jan F.、Barbosa-Lima Giselle
Instituto Nacional de Infectologia (INI), Funda??o Oswaldo Cruz (Fiocruz)Instituto Nacional de Infectologia (INI), Funda??o Oswaldo Cruz (Fiocruz)Center for Infection and Immunity, Mailman School of Public Health, Columbia UniversityLaborat¨?rio de V¨arus Respirat¨?rio e do SarampoCenter for Infection and Immunity, Mailman School of Public Health, Columbia UniversityLaborat¨?rio de ImunofarmacologiaInstituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ)Laborat¨?rio de Flaviv¨arusInstituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ)||SAGE/COPPE, UFRJ, Rio de JaneiroSecretaria Municipal de Sa¨2de, Rio de JaneiroNational Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS)Center for Infection and Immunity, Mailman School of Public Health, Columbia UniversityCenter for Infection and Immunity, Mailman School of Public Health, Columbia UniversitySecretaria Municipal de Sa¨2de, Rio de JaneiroInstituto Nacional de Infectologia (INI), Funda??o Oswaldo Cruz (Fiocruz)Center for Infection and Immunity, Mailman School of Public Health, Columbia UniversityLaborat¨?rio de ImunofarmacologiaLaborat¨?rio de Flaviv¨arusInstituto Nacional de Infectologia (INI), Funda??o Oswaldo Cruz (Fiocruz)||Laborat¨?rio de Imunofarmacologia||National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS)Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ)Center for Infection and Immunity, Mailman School of Public Health, Columbia UniversityLaborat¨?rio de AIDS e imunologia Molecular, Instituto Oswaldo Cruz (IOC)Laborat¨?rio de ImunofarmacologiaLaborat¨?rio de Flaviv¨arusLaborat¨?rio de Flaviv¨arusLaborat¨?rio de Flaviv¨arusInstituto Nacional de Infectologia (INI), Funda??o Oswaldo Cruz (Fiocruz)Instituto Nacional de Infectologia (INI), Funda??o Oswaldo Cruz (Fiocruz)||D?ˉOr Institute for Research and Education (IDOR)Center for Infection and Immunity, Mailman School of Public Health, Columbia UniversityInstituto Nacional de Infectologia (INI), Funda??o Oswaldo Cruz (Fiocruz)
医学研究方法医药卫生理论基础医学
ChikungunyaarbovirusessurveillanceECSABrazilVirCapSeq-VERT
Vieira Yasmine Rangel,Vizzoni Alexandre,Jain Komal,Mesquita Milene,Bhuva Nishit,Monteiro Ana Paula Teixeira,Leomil Luciana,Torres Maria C.,Thompson Fabiano L.,Durovni Betina,Morel Carlos M.,Lipkin W. Ian,Mishra Nischay,Lemos Cristina,Cerbino-Neto Jos¨|,Thakkar Riddhi,Calheiros Andrea Surrage,de Filippis Ana Maria Bispo,Souza Thiago Moreno L.,Tschoeke Diogo A.,Ng James,Delatorre Edson,Bozza Patr¨acia T.,de Mendon?a Marcos Cesar Lima,dos Santos Rodrigues Cintia Damasceno,Nogueira Rita Maria Ribeiro,Luiz Raul Leal Faria,Bozza Fernando A.,Gogarten Jan F.,Barbosa-Lima Giselle.Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection[EB/OL].(2025-03-28)[2025-07-09].https://www.biorxiv.org/content/10.1101/502443.点此复制
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