三焦针法与黄地散联用对海马NSCs移植后SAMP8行为学改变的影响

Stem cells neural (NSCs) plays an important role in the pathogenesis of neurodegenerative diseases, and NSCs transplantation has brought a great prospect in the treatment of nerve regeneration. Previous studies have shown that, based on the Sanjiao theory, Sanjiao acupuncture and HuangDiSan has remarkable curative effect on Alzheimer's disease and vascular dementia and other neurodegenerative disease. In this paper, SAM were divided into SAMR1 group, SAMP8 group, NSCs group, acupuncture group, medicine group and the combination of acupuncture and medicine group, with 10 mice in each group. Morris water maze was applied to observe the effects on the behavior changes of SAM after NSCs transplantation in hippocampus. Results showed that when compared to SAMP8, the escape latency of groups after NSCs transplantation was significantly shortened (P<0.05); when compare to NSCs group, the escape latency of acupuncture group, medicine group and combination group was significantly shortened (P<0.05); when compare to acupuncture or medicine group, the escape latency of combination group was significantly shortened (P<0.05). It is suggested that acupuncture, medicine and the combination of acupuncture and medicine all could effectively improve the dementia symptom of mice, but the therapeutic effect of the combination of acupuncture and medicine was better than that of acupuncture or medicine alone.