基于“T-tube”模型的中心动脉脉搏波无创双通道盲辨识
Estimation of central aortic pulse wave based on dual-channel blind system identification
人体中心动脉脉搏波(Central Aortic Pulse wave, CAP)同心血管系统事件密切相关,但是目前临床CAP主要是有创测量,而采用传递函数法来无创估计CAP,仍不能满足临床模型时变的需求。因此,本论文提出了由两路人体外周动脉脉搏波(Peripheral Artery Pulse wave, PAP)来估计CAP的多通道盲辨识(Multi-channel Blind System Identification, MBSI)算法,旨在实现心血管系统中心动脉脉搏波的实时无创连续监测。本论文首先综述了课题研究的背景和意义,回顾了前人提出的CAP无创传递函数估计方法。接下来介绍了心血管系统生理结构和建模方法,详述了心血管系统的双通道"T-tube"这一"灰箱"模型,本模型不仅为MBSI算法提供了理论依据,还为后续验证基于MBSI算法的"黑箱"模型求解提供了仿真实验平台。本论文首先将心血管系统"灰箱"模型转化成为"黑箱"模型,接着采用MBSI方法求解。本论文还证明了心血管系统IIR模型特性可由中低阶FIR模型逼近,大大简化了MBSI算法。采用了"T-tube"模型数据验证,结果表明MBSI算法稳定性较好,估计出的CAP波形形态整体误差百分比小于7.2%,收缩压误差小于4.6 mmHg,舒张压误差小于4.2 mmHg。
entral Aortic Pulse wave (CAP) is very important in the prediction and treatment of Cardiovascular System (CVS) diseases because it provides tremendous physiological and pathological information of human CVS. In order to monitor CVS non-invasively and effectively, a new method based on Multi-channel Blind System Identification (MBSI) was proposed in this paper to reconstruct CAP from two channel noninvasive Peripheral Aortic Pulse wave (PAP). Background, significance and relative achievements of former research works were introduced in the introduction of the paper. A "gray box" model of CVS was designed based on two-channel "T-tube" model, providing the theoretic foundation for MBSI algorithm. Effectiveness of the MBSI algorithm can be verified by the data from the "T-tube" model. In this paper, the equivalence of the IIR and high order FIR function has been proved. Based on this approximation, this paper successfully converts the IIR model into a FIR model, which greatly simplifies the MBSI algorithm. Verification results show that MBSI algorithm can estimate CAP stably and accurately. The overall error rate, error of systolic pressures and error of diastolic pressures produce by the MBSI algorithm are less than 7.2%, 4.6 mmHg, 4.2 mmHg respectively.
王璐、冯澍婷、徐礼胜
医药卫生理论医学研究方法基础医学
中心动脉脉搏波外周动脉脉搏波“T-tube”模型多通道盲辨识
entral aortic pulse wavePeripheral artery pulse waveT-tube modelMulti-channel blind system identification
王璐,冯澍婷,徐礼胜.基于“T-tube”模型的中心动脉脉搏波无创双通道盲辨识[EB/OL].(2013-05-07)[2025-08-23].http://www.paper.edu.cn/releasepaper/content/201305-100.点此复制
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