线粒体中的微RNA及其相关功能

Mitochondria plays an important role in the energy metabolism, signaling pathways and cell vitality. Mitochondrial dysfunction can cause various diseases, especially the organization needs high energy such as skeletal muscles, heart, kidneys and central nervous system. Mitochondria has its own genome. MicroRNA could suppress the translation or inhibit the degradation of mRNA to inhibit gene expression by recruiting the microRNA silence complex. MicroRNA mainly exist in the cytoplasm and few in the nucleus and extracellular that play its function. At present, studies have found that microRNA can enter the mitochondria and targeting the mitochondrial genome. This paper will mainly review the microRNAs in mitochondria and their functions in the mitochondria.