B淋巴组织恶性肿瘤中枢神经系统浸润及其检测
entral nervous system infiltration of B lymphoblastic malignancies and detection
淋巴组织恶性肿瘤大部分是属于B细胞谱系，临床研究发现，侵袭性白血病以及淋巴瘤常有中枢神经系统（central nervous system, CNS）累及。这些恶性肿瘤的CNS累及可出现于疾病的发生、疾病的进展或者疾病的复发时出现。脑脊液（cerebrospinal fluid, CSF）的实验室检查在CNS疾病的诊断过程中发挥着重要作用。针对CSF，常规的细胞学检查敏感度低，常用的技术如流式细胞技术以及传统的PCR均有所受限，新近的BIO-MED PCR有着较大的优势，本文就B淋巴组织恶性肿瘤中枢神经系统浸润及其检测方法进行综述。
Lymphoid tissue malignancies, most belong to the B cell lineage (90%-95%). Central nervous system (CNS) involvement is often associated with aggressive leukemias and lymphomas. CNS disease may be identified at diagnosis, during disease progression or recurrence of malignancies. Examination of cerebrospinal fluid (CSF) plays an important role in the diagnosis of CNS disease. Conventional cytology is known to have low sensitivity. Flow cytometry and PCR analysis of CSF has been also shown to have limitations. In recent years, BIO-MED PCR has a great advantage. In this article, we review the CNS involvement of B lymphoid tissue malignancies and the detection methods.)
李金梅、李英花、周晋、李慧波
肿瘤学神经病学、精神病学医学研究方法
B淋巴组织恶性肿瘤中枢神经系统浸润检测
B lymphoblastic malignanciesCentral nervous system infiltraiondetection methods
李金梅,李英花,周晋,李慧波.B淋巴组织恶性肿瘤中枢神经系统浸润及其检测[EB/OL].(2016-06-03)[2025-08-05].http://www.paper.edu.cn/releasepaper/content/201606-299.点此复制
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