双硝基苯腙齐墩酸衍生物的合成及其类破骨细胞形成抑制活性(II)
Synthesis and inhibitory activity on the formation of Osteoclast-like cells of dinitrophenyhydrazone oleanolic acid derivatives (II)
本文对齐墩果酸A环进行了结构修饰，合成了一系列双硝基苯腙的天然氨基酸衍生物，其结构经过1H NMR, 13C NMR和 Mass的确证。测定了1, 25-(OH)2D3诱导的类破骨细胞（OLCs）形成的抑制作用。结果表明双硝基苯腙3和甘氨酸甲酯3a具有很强的抑制OCLs的作用。
In this paper, a series of natural 冄-amino acid derivatives of dinitrophenyhydrazone oleanolic acid were synthesized by modifying A ring. The structure of the substances was confirmed by 1H NMR, 13C NMR and Mass. They were tested for their inhibitory activity on 1冄,25-dihydroxy vitamin D3 [1
李建新、李俊峰
基础医学生物化学药学
齐墩果酸衍生物，天然氨基酸，抑制，类破骨细胞形成
oleanolic acid derivativesnature amino acidinhibitorOsteoclast formation
李建新,李俊峰.双硝基苯腙齐墩酸衍生物的合成及其类破骨细胞形成抑制活性(II)[EB/OL].(2009-01-01)[2025-08-05].http://www.paper.edu.cn/releasepaper/content/200901-2.点此复制
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