Effectiveness and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-analysis
Effectiveness and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-analysis
ABSTRACT MSC (a.k.a. mesenchymal stem cell or medicinal signaling cell) cell therapies have shown promise in decreasing mortality in ARDS and suggest benefits in treatment of COVID-19 related ARDS. We performed a meta-analysis of published trials assessing the effectiveness and adverse events (AE) of MSC cell therapy in individuals hospitalized for COVID-19. Systematic searches were performed in multiple databases through April 8th, 2021. Reports in all languages including randomized clinical trials (RCTs), comparative observational studies, and case series/case reports were included. Random effects model was used to pool outcomes from RCTs and comparative observational studies. Outcome measures included all-cause mortality, serious adverse events (SAEs), AEs, pulmonary function, laboratory and imaging findings. A total of 413 patients were identified from 25 studies, which included 8 controlled trials (3 RCTs), 5 comparative observational studies, (n=300) and 17 case-series/case reports (n=113). The patients age was 60.5 years (mean), 33.7% were women. When compared with the control group, MSC cell therapy was associated with reduction in all-cause mortality (RR=0.31, 95% CI: 0.12 to 0.75, I2=0.0%; 3 RCTs and 5 comparative observational studies, 300 patients), reduction in SAEs (IRR=0.36, 95% CI: 0.14 to 0.90, I2=0.0%; 3 RCTs and 2 comparative studies, n=219), no significant difference in AE rate. A sub-group with pulmonary function studies suggested improvement in patients receiving MSC. These findings support the potential for MSC cell therapy to decrease all-cause mortality, reduce SAEs, and improve pulmonary function compared to conventional care. Large scale double-blinded, well-powered RCTs should be conducted to further explore these results.
Engelberg-Cook Erica、Allickson Julie G.、Kubrova Eva、Caplan Arnold I.、Hare Joshua M.、Ricordi Camillo、Pepine Carl J.、Rodriguez Ricardo L.、Richards Elaine M.、Mallea Jorge M.、Bu Guojun、Kurtzberg Joanne、Nayfeh Tarek、March Keith、Wang Zhen、Qu Wenchun、Saadi Samer、Siddik Abu Bakar、Pascual Jorge M.、Sanfilippo Fred P.
Department of NeuroscienceCenter for Regenerative MedicineDepartment of Physical Medicine and RehabilitationSkeletal Research Center, Biology Department, Case Western Reserve University OhioInterdisciplinary Stem Cell Institute and Cardiology Division, Department of Medicine, University of Miami, Miller School of MedicineDepartment of Surgery, Diabetes Research Institute and Cell Transplant Center, University of Miami Miller School of MedicineDivision of Cardiovascular Medicine, and Center for Regenerative Medicine, University of FloridaCo-Chair Regenerative Medicine Committee, American Society Plastic SurgeonsDepartment of Physiology and Functional Genomics, Center of Regenerative Medicine, University of FloridaDivision of Pulmonary Department of MedicineCenter for Regenerative Medicine||Department of NeuroscienceMarcus Center for Cellular Cures, Duke University School of MedicineEvidence-Based Practice Center||Robert D. and Patricia E. Kern Center for the Science of Health Care DeliveryDivision of Cardiovascular Medicine, Center for Regenerative Medicine, University of FloridaEvidence-Based Practice Center||Robert D. and Patricia E. Kern Center for the Science of Health Care DeliveryDepartment of Pain Medicine||Center for Regenerative MedicineEvidence-Based Practice Center||Robert D. and Patricia E. Kern Center for the Science of Health Care DeliveryDepartment of Pain MedicineDivision of Pulmonary Department of MedicineDepartment of Pathology and Laboratory Medicine, Department of Health Policy and Management, Emory University
医学研究方法内科学基础医学
MSCCOVIDCytokine stormPulmonaryHospital recovery
Engelberg-Cook Erica,Allickson Julie G.,Kubrova Eva,Caplan Arnold I.,Hare Joshua M.,Ricordi Camillo,Pepine Carl J.,Rodriguez Ricardo L.,Richards Elaine M.,Mallea Jorge M.,Bu Guojun,Kurtzberg Joanne,Nayfeh Tarek,March Keith,Wang Zhen,Qu Wenchun,Saadi Samer,Siddik Abu Bakar,Pascual Jorge M.,Sanfilippo Fred P..Effectiveness and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-analysis[EB/OL].(2025-03-28)[2025-08-13].https://www.medrxiv.org/content/10.1101/2021.10.05.21264559.点此复制
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