钠-葡萄糖共转运蛋白-2抑制剂与二肽基肽酶-4抑制剂对老年2型糖尿病患者体重和身体成分的影响比较

ObjectiveThis study compared the effects of dapagliflozin and linagliptin on weight and body composition in elderly T2DM patients who had already been treated with metformin for poor blood sugar control.MethodsTotally 106 elderly patients with type 2 diabetes who had received metformin treatment and had HbA1c levels of more than 7.0% were randomly divided into dapagliflozin and linagliptin groups. Bioimpedance analysis was used to assess body composition before and after the study.ResultsThe average body weight change from baseline to 24 weeks in the dapagliflozin group was -3.78 kg . Dapagliflozin also significantly reduced muscle massand total body protein. Compared with linagliptin, dapagliflozin resulted in a greater decrease in body fat mass from baseline to week 24, the statistical difference was significant.ConclusionDapagliflozin significantly reduces body weight, including body fat and lean weight, and should be used with caution in elderly frail patients.