褐色脂肪组织分化及其调节机制探讨
Brown adipocyte tissue differentiation and control mechanism
BMP7 (bone morphogenetic proteins7)是一种一类转化生长因子-β超家族成员(transforming growth, TGF-β)的多功能分泌型信号分子，在胚胎发生、个体形成、非对称器官的形成、胚胎的发育和损伤组织的修复中起关键作用。最近研究，发现BMP 7 能促进褐色脂肪细胞的分化，可能是由于BMP7诱导PRDM16 及PGC-1α等的基因表达，进一步增加了UCP1等基因的表达，最终诱导褐色脂肪细胞中线粒体的生物生成和随后的细胞分化。这些研究显示通过激活 BMP7和PRDM16 来增加褐色脂肪组织在治疗肥胖及相关疾病方面具有很大潜力。
BMP7 (bone morphogenetic proteins7) is one of members of the transforming growth factor-β (TGF-β) superfamily and control multiple key steps of embryonic development and differentiation. In recent studies, people found that BMP7-induced UCP1 expression was markedly diminished in brown preadipocytes deficient in both PRDM16 and PGC (PGC-1α and PGC-1β), it ultimately induces BAT mitochondrial cells in the biological production and cell differentiation. These researches indicate the potential to treat obesity and related diseases through activating BMP7 and PRDM16 to produce brown adipose tissue.
蔡金红、张麟、练硝、王政昆、朱万龙
分子生物学细胞生物学生物化学
褐色脂肪组织(BAT)干细胞分化骨形态发生蛋白7(BMP7)
Brown adipose tissue (BAT)Stem cell differentiationBone morphogenetic proteins7 (BMP7)
蔡金红,张麟,练硝,王政昆,朱万龙.褐色脂肪组织分化及其调节机制探讨[EB/OL].(2010-07-09)[2025-08-04].http://www.paper.edu.cn/releasepaper/content/201007-205.点此复制
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