2-酮基-3-脱氧辛酸合成的研究进展
Advances in synthesis of 3-deoxy-oct-2-ulosonic acid
摘要
2-酮基-3-脱氧辛酸(2-Keto-3-deoxy-D-manno-octulosonic acid , KDO) 属于3-脱氧辛酸家族，是一种重要的单糖，是细菌脂多糖（LPS，内毒素）和荚膜多糖（CPS）的一个特征组分，对细菌细胞的生存和发展至关重要。对KDO的重要作用进行了介绍，并报告了近年来合成KDO的多种方法，主要包括化学合成法、天然提取法和酶合成法。Abstract
2-Keto-3-deoxy-D-manno-octulosonic acid as a family of 3-deoxidization octylic acid, is an important monosaccharide and a key component of bacterial lipopolysaccharides (LPS) and capsular polysaccharide (CPS). KDO is crucial for the survival and development of bacterial cells. This article introduces the preparation strategy of KDO during latest years, mainly including chemical synthesis (semi-synthesis method and full synthesis), natural extraction and enzymatic synthesis. 关键词
2-酮基-3-脱氧辛酸/脂多糖/全合成/半合成/酶合成Key words
3-deoxy-oct-2-ulosonic acid/lipopolysaccharide/full synthesis/semi-synthesis/enzymatic synthesis引用本文复制引用
胡静,蔡军涛,尹健,徐步云.2-酮基-3-脱氧辛酸合成的研究进展[EB/OL].(2018-04-13)[2025-12-06].http://www.paper.edu.cn/releasepaper/content/201804-138.学科分类
生物化学/生物科学研究方法、生物科学研究技术/微生物学
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