Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide
Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide
ABSTRACT Background and PurposeUp to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Subcortical regions play critical roles in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behavior at different timepoints after stroke. MethodsWe pooled high-resolution T1-weighted MRI brain scans and behavioral data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimotor behavior to non-lesioned subcortical volumes (Bonferroni-corrected, p<0.004). We tested subacute (≤90 days) and chronic (≥180 days) stroke subgroups separately, with exploratory analyses in early stroke (≤21 days) and across all time. Sub-analyses in chronic stroke were also performed based on class of sensorimotor deficits (impairment, activity limitations) and side of lesioned hemisphere. ResultsWorse sensorimotor behavior was associated with a smaller ipsilesional thalamic volume in both early (n=179; d=0.68) and subacute (n=274, d=0.46) stroke. In chronic stroke (n=404), worse sensorimotor behavior was associated with smaller ipsilesional putamen (d=0.52) and nucleus accumbens (d=0.39) volumes, and a larger ipsilesional lateral ventricle (d=-0.42). Worse chronic sensorimotor impairment specifically (measured by the Fugl-Meyer Assessment; n=256) was associated with smaller ipsilesional putamen (d=0.72) and larger lateral ventricle (d=-0.41) volumes, while several measures of activity limitations (n=116) showed no significant relationships. In the full cohort across all time (n=828), sensorimotor behavior was associated with the volumes of the ipsilesional nucleus accumbens (d=0.23), putamen (d=0.33), thalamus (d=0.33), and lateral ventricle (d=-0.23). ConclusionsWe demonstrate significant relationships between post-stroke sensorimotor behavior and reduced volumes of subcortical gray matter structures that were spared by stroke, which differ by time and class of sensorimotor measure. These findings may provide additional targets for improving post-stroke sensorimotor outcomes.
Westlye Lars T.、Wittenberg George F.、Yu Chunshui、Wolf Steven L.、Zavaliangos-Petropulu Artemis、Lang Catherine E.、Bhattacharya Anup K.、Bigjahan Bavrina、Byblow Winston D.、Cassidy Jessica M.、Ciullo Valentina、Egorova Natalia、Feng Wuwei、Hayward Kathryn S.、Holguin Jess A.、Hwang Darryl H.、Khlif Mohamed Salah、Margetis John L.、Mohamed Feroze B.、Nordvik Jan Egil、Piras Fabrizio、Shiroishi Mark S.、Soekadar Surjo R.、Stinear Cathy M.、Suri Anisha、Hordacre Brenton、Thielman Gregory T.、Kuceyeski Amy、Brodtmann Amy、Lotze Martin、Buetefisch Cathrin M.、Thijs Vincent N.、Schambra Heidi M.、Ward Nick S.、Craddock Richard C.、Kim Bokkyu、Seo Na Jin、Banaj Nerisa、Liu Jingchun、Robertson Andrew D.、Kautz Steven A.、Wong Kristin A.、Ramos-Murguialday Ander、Liew Sook-Lei、Revill Kate P.、Roberts Pamela、Gregory Chris M.、Dula Adrienne N.、Petoe Matthew A.、Jahanshad Neda、Tang Wai Kwong、Spalletta Gianfranco、Thompson Paul M.、MacIntosh Bradley J.、Fercho Kelene A.、Conforto Adriana B.、Lohse Keith R.、Barisano Giuseppe、Schweighofer Nicolas、Winstein Carolee J.、Borich Michael R.、Hanlon Colleen A.、Boyd Lara A.、Raju Sharmila、Vecchio Daniela、Cramer Steven C.、Baugh Lee A.、Lo Bethany、Kim Hosung、Lin David、Wang Junping
Department of Psychology, University of Oslo||NORMENT, Division of Mental Health and Addiction, Oslo University HospitalDepartment of Neurology, University of Pittsburgh||Neurology, Department of Veterans Affairs Pittsburgh Healthcare SystemDepartment of Radiology, Tianjin Medical University General Hospital||Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General HospitalDivision of Physical Therapy Education, Department of Rehabilitation Medicine, Department of Medicine, and Department of Cell Biology, Emory University School of Medicine||Nell Hodgson Woodruff School of Nursing, Emory University||Center for Visual and Neurocognitive RehabilitationNeuroscience Graduate Program, University of Southern California||Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern CaliforniaDepartments of Physical Therapy, Occupational Therapy, and Neurology, Washington University School of MedicineMallinckrodt Institute of Radiology, Washington University School of Medicine in St. LouisDepartment of Radiology, Keck School of Medicine, University of Southern CaliforniaDepartment of Exercise Sciences and Centre for Brain Research, University of AucklandAllied Health Science, University of North Carolina at Chapel HillLaboratory of Neuropsychiatry, IRCCS Santa Lucia FoundationFlorey Institute of Neuroscience and Mental Health, University of Melbourne||Melbourne School of Psychological Sciences, University of MelbourneDepartment of Health Sciences & Research, Medical University of South CarolinaFlorey Institute of Neuroscience and Mental Health, University of Melbourne||Department of Physiotherapy, University of Melbourne||NHMRC CRE in Stroke Rehabilitation and Brain Recovery, University of MelbourneChan Division of Occupational Science and Occupational Therapy, University of Southern CaliforniaDepartment of Radiology, Keck School of Medicine, University of Southern California||Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern CaliforniaFlorey Institute of Neuroscience and Mental Health, University of MelbourneChan Division of Occupational Science and Occupational Therapy, University of Southern CaliforniaJefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson UniversityCatoSenteret Rehabilitation CenterLaboratory of Neuropsychiatry, IRCCS Santa Lucia FoundationImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California||Department of Radiology, Keck School of Medicine, University of Southern CaliforniaClinical Neurotechnology Laboratory, Dept. of Psychiatry and Psychotherapy, Charit¨| - University Medicine Berlin,Department of Medicine, University of AucklandDepartment of Electrical and Computer Engineering, Swanson School of Engineering, University of PittsburghInnovation, IMPlementation and Clinical Translation (IIMPACT) in Health, Allied Health and Human Performance, University of South AustraliaDepartment of Physical Therapy and Neuroscience, University of the SciencesDepartment of Radiology, Weill Cornell MedicineFlorey Institute of Neuroscience and Mental Health, University of Melbourne||Eastern Cognitive Disorders Clinic, Monash UniversityDepartment of Diagnostic Radiology, University Medicine GreifswaldDepartment of Rehabilitation Medicine, Emory University||Department of Neurology, School of Medicine, Emory University||Department of Radiology, Emory UniversityFlorey Institute of Neuroscience and Mental Health, University of Melbourne||Department of NeurologyDepartment of Neurology, Langone School of Medicine, New York UniversityUCL Queen Square Institute of NeurologyDepartment of Diagnostic Medicine, Dell Medical School, University of Texas at AustinDepartment of Physical Therapy Education, College of Health Professions, SUNY Upstate Medical UniversityDepartment of Health Sciences & Research, Medical University of South Carolina||Ralph H. Johnson VA Medical Cente||Department of Rehabilitation Sciences, Medical University of South CarolinaLaboratory of Neuropsychiatry, IRCCS Santa Lucia FoundationDepartment of Radiology, Tianjin Medical University General HospitalCanadian Partnership for Stroke Recovery, Sunnybrook Research Institute, University of Toronto||Department of Kinesiology, University of WaterlooDepartment of Health Sciences & Research, Medical University of South Carolina||Ralph H. Johnson VA Medical CentePhysical Medicine & Rehabilitation, Dell Medical School, University of Texas at AustinInstitute of Medical Psychology and Behavioral Neurobiology, University of T¨1bingenChan Division of Occupational Science and Occupational Therapy, University of Southern California||Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern CaliforniaFacility for Education and Research in Neuroscience, Emory UniversityChan Division of Occupational Science and Occupational Therapy, University of Southern California||Department of Physical Medicine and Rehabilitation, Cedars-Sinai, Los Angeles||California Rehabilitation InstituteDepartment of Health Sciences & Research, Medical University of South CarolinaDepartment of Diagnostic Medicine, Dell Medical School, University of Texas at AustinBionics Institute||Department of Medicine and Centre for Brain Research, University of AucklandImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern CaliforniaDepartment of Psychiatry, Faculty of Medicine, the Chinese University of Hong KongLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation||Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of MedicineImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern CaliforniaHurvitz Brain Sciences, Sunnybrook Research Institute||Department of Medical Biophysics, University of TorontoCivil Aerospace Medical Institute, US Federal Aviation Administration||Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South DakotaHospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo||Hospital Israelita Albert EinsteinDepartment of Health and Kinesiology, University of UtahNeuroscience Graduate Program, University of Southern California||Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern CaliforniaBiokinesiology and Physical Therapy, Ostrow School of Medicine, University of Southern CaliforniaBiokinesiology and Physical Therapy, Ostrow School of Medicine, University of Southern California||Department of Neurology, University of CaliforniaDepartment of Rehabilitation Medicine, Emory UniversityCancer Biology, Wake Forest School of Medicine||College of Health Professions, Medical University of South CarolinaDepartment of Physical Therapy & the Djavad Mowafaghian Centre for Brain Health, Facutly of Medicine, University of British ColumbiaDepartment of Neurology, Langone School of Medicine, New York UniversityLaboratory of Neuropsychiatry, IRCCS Santa Lucia FoundationCalifornia Rehabilitation Institute||Department of Neurology, University of CaliforniaBasic Biomedical Sciences, Sanford School of Medicine, University of South Dakota||Sioux Falls VA Health Care System||Center for Brain and Behavior Research||Sanford ResearchChan Division of Occupational Science and Occupational Therapy, University of Southern CaliforniaMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern CaliforniaCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital
神经病学、精神病学医学研究方法基础医学
strokerehabilitationsensorimotor behaviorMRIsubcortical volumes
Westlye Lars T.,Wittenberg George F.,Yu Chunshui,Wolf Steven L.,Zavaliangos-Petropulu Artemis,Lang Catherine E.,Bhattacharya Anup K.,Bigjahan Bavrina,Byblow Winston D.,Cassidy Jessica M.,Ciullo Valentina,Egorova Natalia,Feng Wuwei,Hayward Kathryn S.,Holguin Jess A.,Hwang Darryl H.,Khlif Mohamed Salah,Margetis John L.,Mohamed Feroze B.,Nordvik Jan Egil,Piras Fabrizio,Shiroishi Mark S.,Soekadar Surjo R.,Stinear Cathy M.,Suri Anisha,Hordacre Brenton,Thielman Gregory T.,Kuceyeski Amy,Brodtmann Amy,Lotze Martin,Buetefisch Cathrin M.,Thijs Vincent N.,Schambra Heidi M.,Ward Nick S.,Craddock Richard C.,Kim Bokkyu,Seo Na Jin,Banaj Nerisa,Liu Jingchun,Robertson Andrew D.,Kautz Steven A.,Wong Kristin A.,Ramos-Murguialday Ander,Liew Sook-Lei,Revill Kate P.,Roberts Pamela,Gregory Chris M.,Dula Adrienne N.,Petoe Matthew A.,Jahanshad Neda,Tang Wai Kwong,Spalletta Gianfranco,Thompson Paul M.,MacIntosh Bradley J.,Fercho Kelene A.,Conforto Adriana B.,Lohse Keith R.,Barisano Giuseppe,Schweighofer Nicolas,Winstein Carolee J.,Borich Michael R.,Hanlon Colleen A.,Boyd Lara A.,Raju Sharmila,Vecchio Daniela,Cramer Steven C.,Baugh Lee A.,Lo Bethany,Kim Hosung,Lin David,Wang Junping.Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide[EB/OL].(2025-03-28)[2025-05-23].https://www.biorxiv.org/content/10.1101/2020.11.04.366856.点此复制
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