复方阿胶浆对保护环磷酰胺导致移植性lewis肺癌小鼠外周血象研究

Objective: To investigate the impact of Compound e-Jiao slurry (CEJS) on the decline of peripheral blood caused by Cyclophosphamide (CTX) in lewis pulmonary carcinoma xenografts in mice. Methods: 60 C57BL/6 mice were randomly divided into six groups including the model group, CTX, CEJS, high-dose CEJS joint CTX, middle-dose CEJS joint CTX and low-dose CEJS joint CTX group. Sampled the tail vein blood of the mice separately on the 7th day and the 13th day during experiment, then detected peripheral blood by the Beckman Coulter Ac. T diff/Ac. T diff2. Results: Compared the numerical value of WBC with other groups on the 7th day after treatment, the CTX group declined more obviously（p<0.05～0.01）. Compared the numerical value of RBC and HGB with the model group on the 13th day after treatment, the CTX and low-dose CEJS joint CTX group were lower significantly（p<0.01）and the numerical value of RBC and HGB increased in middle-dose CEJS joint CTX Compared with CTX group（p<0.05）.The WBC amount of CTX and every combination group increased more rapidly compared with the model and middle-dose CEJS joint CTX group（p<0.01）. Conclusion: CEJS could ease the decline of mice peripheral blood caused by CTX and improve the hematopoietic function.