Research Progress of Anxiety and Depression Related to Chronic Fatigue Syndrome

he relationship between fatigue and diseases continues to receive widespread attention and fatigue is becoming an important public health issue. The World Health Organization added overexertion to the International Classification of Diseases in May, 2019, which had took effect globally in 2022. The concept of chronic fatigue syndrome （CFS） was proposed earlier, while its etiology and pathogenesis still remain unclear till now, resulting in lacking of specific therapies, which may be due to the involvement of multiple systems and the difficulties in distinguishing CFS symptoms from anxiety/depression, the complexity of the diagnosis and treatment of thedisease and researches on it are also increased. This review initially investigates the characteristics of CFS associated with anxiety/depression, further explores the similarities and differences in indicator change characteristics between CFS and anxiety/depression in terms of the current research status on biological indicators, imaging abnormalities and treatment, in order to provide new ideas for the diagnosis and typing of CFS, and provide suggestions for conducting clinical and basic researches on the disease.