过敏性肺炎免疫调控机制的研究进展

Inhalation of fugi contaminated organic dust in occupational environment induced hypersensitivity pneumonitis, repeated occurrence could led to the irreversible lung fibrosis, which brings great harm to workers in agriculture and industry. Immune cells, such as lymphocytes, play a critical role in the pathological process of hypersensitivity pneumonitis. The balance and the transformation of multiple types of Th cells influenced the development and the prognoses of hypersensitivity pneumonitis. However, the immune regulatory mechanism is not clear yet. Regulatory T cells were testified to modulate hypersensitivity pneumonitis by affecting Th immune response. Newly research demonstrate that regulatory B cells could affect many inflammatory diseases, but the detailed mechanism still need further investigation. This article systematically reviewed the mechanism of regulatory immune cells in the development of hypersensitivity pneumonitis. And the powerful experimental and theoretical foundation will be provided to help prevention and treatment of hypersensitivity pneumonitis.