新疆地区食管鳞状细胞癌组织中中微染色体维持蛋白-2和葡萄糖调节蛋白-94的表达及其临床病理学意义研究

objective: To investigate expression and clinical pathology significance of MCM-2 and Grp94 in esophageal squamous cell carcinomant. Methods: Envision immunohistochemical method was used to detect the expressions of MCM-2 and Grp94 in 80 cases of esophageal squamous cell carcinoma and in 15 cases of normal tissues, and to analyse the relationship between them and different clinical pathological factors. Results: (1) The positive frequency of MCM-2 and Grp94 in esophageal squamous cell carcinoma tissues was separately 50.0％（40/80）and 68.8％（55/80）.(2) The expressions of MCM-2 of differentiation and lymphnode metastasis in esophageal squamous cell carcinomant there were difference between them (P<0.05). Compared with them.The expressions of MCM-2 of infiltrating in esophageal squamous cell carcinomant, compared with them,there is no difference between them (Р＞0.05).（3）The expressions of Grp-94 of differentiation and infiltrating in esophageal squamous cell carcinomant,there were difference between them (P<0.05), compared with them, The expressions of Grp-94 of lymphnode metastasis in esophageal squamous cell carcinomant, compared with them, there is no difference between them (P＞0.05). Conclusion:(1) It is suggested that MCM-2 and Grp-94 play a role in pathogenesis. (2) The expressions of MCM-2 had a closed ralationgship with tumor metastasis. (3) The expressions of Grp-94 had a closed relationship with tumor development.