Contrast-Enhanced Magnetic Resonance Imaging Based T1-Mapping and Extracellular Volume Fractions are Associated with Peripheral Artery Disease
Contrast-Enhanced Magnetic Resonance Imaging Based T1-Mapping and Extracellular Volume Fractions are Associated with Peripheral Artery Disease
Abstract BackgroundExtracellular volume fraction (ECV), measured with contrast-enhanced magnetic resonance imaging (CE-MRI), has been utilized to study myocardial fibrosis but its role in peripheral artery disease (PAD) remains unknown. We hypothesized that T1-mapping and ECV differ between PAD patients and matched-controls. Methods and ResultsA total of 37 individuals (18 PAD, 19 controls) underwent 3.0T CE-MRI at the mid-calf. T1-mapping was done before and after gadolinium contrast with a motion corrected Modified Look Locker Inversion Recovery (MOLLI) pulse sequence. T1 values were calculated with a 3-parameter Levenberg-Marquardt curve fitting algorithm. T1-maps were quantified in 5 calf muscle compartments (anterior [AM], lateral [LM], and deep posterior [DM] muscle groups; soleus [SM], and gastrocnemius [GM] muscles). Averaged peak blood pool T1 values were obtained from the posterior (PT) and anterior tibialis (AT); and peroneal artery (PE). PAD ECV was calculated for each muscle group. T1 values and ECV are heterogeneous across calf muscle compartments. Native peak T1 values of the AM, LM, and DM were significantly higher in PAD patients compared to controls (all p<0.028). ECV of the AM and SM were significantly higher in PAD patients compared to controls (AM: 26.4% (21.2, 31.6) vs. 17.3% (10.2, 25.1), p=0.046; SM: 22.7% (19.5, 27.8) vs. 13.8% (10.2, 19.1), p=0.020). ConclusionsNative peak T1 values and ECV fractions of several calf muscle compartments are higher in PAD patients compared with matched-controls. These data suggest a potential utility of ECV to noninvasively determine skeletal muscle fibrosis in PAD.
Gimnich Olga A.、Ballantyne Christie M.、Brunner Gerd、Shah Dipan J.、Taylor Addison A.、Bismuth Jean、Belousova Tatiana、Shieh Michael C.、Fitian Asem
Penn State Heart and Vascular Institute, Pennsylvania State University College of MedicineSection of Cardiovascular Research and Department of Medicine, Baylor College of Medicine||Section of Cardiology, Department of Medicine, Baylor College of MedicinePenn State Heart and Vascular Institute, Pennsylvania State University College of Medicine||Section of Cardiovascular Research and Department of Medicine, Baylor College of MedicineMethodist DeBakey Heart and Vascular Center, Houston Methodist HospitalSection of Cardiovascular Research and Department of Medicine, Baylor College of Medicine||Michael E DeBakey VA Medical CenterDivision of Vascular and Endovascular Surgery, Louisiana State University Health Sciences CenterMethodist DeBakey Heart and Vascular Center, Houston Methodist HospitalSection of Cardiovascular Research and Department of Medicine, Baylor College of MedicinePenn State Heart and Vascular Institute, Pennsylvania State University College of Medicine
医学研究方法基础医学内科学
peripheral artery diseasemagnetic resonance imagingT1 mappingextracellular volume fractionskeletal calf muscle
Gimnich Olga A.,Ballantyne Christie M.,Brunner Gerd,Shah Dipan J.,Taylor Addison A.,Bismuth Jean,Belousova Tatiana,Shieh Michael C.,Fitian Asem.Contrast-Enhanced Magnetic Resonance Imaging Based T1-Mapping and Extracellular Volume Fractions are Associated with Peripheral Artery Disease[EB/OL].(2025-03-28)[2025-07-21].https://www.medrxiv.org/content/10.1101/2023.03.03.23286787.点此复制
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