改性MCM-41的超声触发释药性能研究

In this paper, MCM-41 mesoporous molecular sieves was synthesized by microwave method, ferric nitrate as the iron source was used for preparing Fe-MCM-41. Anticancer drugs 5-fluorouracil (5-FU) as a model drug were assembled into the two materials by the impregnation method. The materials were charactered by the means of fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (XRD), low temperature N2 adsorption. The drug release of assemblies were investigated under routine condition and ultrasonic condition in artificial gastric juice. The results show that: microwave-assisted synthesis successfully prepared ordered mesoporous MCM-41 and Fe-MCM-41, and 5-Fu successfully assembled into the both mesoporous materials. In artificial gastric juice, the drug release rate of the drug assemblies in ultrasonic is better than conventional release .