Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy
Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy
Abstract Reality monitoring is defined as the ability to distinguish internally self-generated information from externally-derived information. The medial prefrontal cortex (mPFC) is a key brain region subserving reality monitoring and has been shown to be activated specifically during the retrieval of self-generated information. However, it is unclear if mPFC is activated during the encoding of self-generated information into memory. If so, it is important to understand whether successful retrieval of self-generated information critically depends on enhanced neural activity within mPFC during initial encoding of this self-generated information. We used magnetoencephalographic imaging (MEGI) to determine the timing and location of cortical activity during a reality-monitoring task involving self generated contextual source memory encoding and retrieval. We found both during encoding and retrieval of self-generated information, when compared to externally-derived information, mPFC showed significant task induced oscillatory power modulation in the beta-band. During initial encoding of self-generated information, greater mPFC beta-band power reductions occurred within a time window of ?700ms to ?500ms prior to vocalization, activity in mPFC that was not observed during encoding of externally-derived information. This mPFC activity during encoding of self-generated information predicted subsequent retrieval accuracy of self-generated information. Beta-band activity in mPFC was also observed during the initial retrieval of self-generated information within a time window of 300 to 500ms following stimulus onset and correlated with accurate retrieval performance of self-generated information. Together, these results further highlight the importance of mPFC in mediating the initial generation and awareness of participants’ internal thoughts.
Hinkley Leighton B.N.、Kothare Hardik、Garrett Coleman、Subramaniam Karuna、Houde John F.、Mizuiri Danielle、Findlay Anne、Nagarajan Srikantan S.
Department of Radiology and Biomedical Imaging, University of CaliforniaDepartment of Radiology and Biomedical Imaging, University of CaliforniaDepartment of Radiology and Biomedical Imaging, University of CaliforniaDepartment of Psychiatry, University of CaliforniaDepartment of Radiology and Biomedical Imaging, University of CaliforniaDepartment of Radiology and Biomedical Imaging, University of CaliforniaDepartment of Radiology and Biomedical Imaging, University of CaliforniaDepartment of Radiology and Biomedical Imaging, University of California
生物科学研究方法、生物科学研究技术生物科学理论、生物科学方法生物科学现状、生物科学发展
self-agencyreality monitoringmedial prefrontal cortexencoding self-generated thoughtsretrieving self-generated thoughts
Hinkley Leighton B.N.,Kothare Hardik,Garrett Coleman,Subramaniam Karuna,Houde John F.,Mizuiri Danielle,Findlay Anne,Nagarajan Srikantan S..Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy[EB/OL].(2025-03-28)[2025-04-28].https://www.biorxiv.org/content/10.1101/437244.点此复制
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