线粒体融合蛋白 2 的结构、功能及其在肝脏疾病中作用机制的研究进展

he liver is the largest metabolic organ in the human bodyand impaired liver function can lead to a variety of acute and chronic liver diseaseswhich can affect the quality of life in mild cases or be life-threatening in severe cases. Thereforeit is important to explore accurate and effective molecular diagnostic markers and therapeutic targets. Mitofusin 2Mfn2is a transmembrane motor protein on the outer membrane of mitochondriaand plays an important role not only in mitochondrial fusion regulationbut also in cell energy metabolismcell apoptosiscell proliferationmitochondrial endoplasmic reticulumERconnections ER stress and mitochondrial autophagyetc. It has been found that abnormal expression or function loss of Mfn2 can lead to abnormal mitochondrial functionwhich in turn leads to a variety of liver diseases. In this papera systematic review of the structure and function of Mfn2 and its mechanisms of action in liver diseases was conducted and found that Mfn2 can be involved in the development of chronic liver diseases through multiple pathwaysand improve liver function through modulating Mfn2 overexpression to further slow down and reverse disease progression. This paper aims to provide a scientific reference for basic research of Mfn2 and liver diseasesas well as its clinical application.