人体肢体结缔组织中组织液流动三维渗流动力学模型分析与针刺信号传递机理
3-D Dynamic Model of the Interstitial fluid flow in Human Connective Tissue and Its Application in the Analysis on the Mechanism of Acupuncture Signal Transmission
本文在对人体上肢穴位深部解剖和宏微观观察与测量的基础上,通过对人体骨间膜处的组织液三维流动建立数学模型研究,了解在特异性分布的毛细血管和胶原纤维下组织液流动的特异性,及组织液流动对肥大细胞壁面切应力的影响。本研究的结果初步解释了针灸作用过程中的循经感传现象和针灸作用机理。当针刺穴位时,穴位处的肥大细胞被激活,产生脱颗粒反应。脱颗中的组胺等物质会引起毛细血管壁通透性的增加,进而引起组织液流动速度的增加和肥大细胞表面的切应力加大,这样会进一步促进肥大细胞的激活,从而释放更多的活性物质,这些物质一部分被静脉端毛细血管吸收进入血液,另一部分则随着组织液的定向流动向远处,并进一步刺激远处的毛细血管和肥大细胞,而组织液的定向流动途径和传统的经络线走向基本吻合,在宏观上就构成了循经感传现象。
On the base of deep part dissection of acupoints on the upper limbs of human body and the micro and macro observation and measurement, we constructed a mathematical model on the flow of the tissue fluid in interosseous membrane. By this model, we get to know the characteristics of the tissue-fluid flow and the influence of tissue-fluid flow on superficial shear stress of mast cell. The results of this study preliminarily explain the feeling-along-meridian phenomenon and the acupuncture mechanism. When being acupunctured, the related mast cells will be activated to discharge particles. The histamine in the particles will increase the transmission capacity of capillary and the velocity of the tissue-fluid flow and the superficial shear stress of related mast cell will be increased, which will once again activate mast cells to discharge active substance. Part of the active substance will be absorbed by capillary and the other part will be passed by tissue fluid to a remote place and it will activate the mast cells and the capillaries there. The directional path of the tissue fluid is approximately the same as the meridian, which forms the phenomenon of feeling-along-meridian on macroscale.
姚伟、丁光宏、党瑞山、沈雪勇、杨静、陈尔瑜
中医学基础医学生理学
组织液流动,经络,肥大细胞针刺
interstitial fluid flow meridians mast cell acupuncture……
姚伟,丁光宏,党瑞山,沈雪勇,杨静,陈尔瑜.人体肢体结缔组织中组织液流动三维渗流动力学模型分析与针刺信号传递机理[EB/OL].(2005-12-22)[2025-08-18].http://www.paper.edu.cn/releasepaper/content/200512-548.点此复制
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