Legumain在肿瘤转移中的作用及以其为靶点的相关治疗方法的研究

Legumain, an asparaginyl endopeptidase, is a kind of stress proteins. The analysis of gene expression profiling and tissue array indicates that legumain is highly expressed in tumor and tumor associated macrophage (TAM). Based on this character, legumain mini-gene vaccine is developed and has been demonstrated to inhibit the growth, metastasis and angiogenesis of tumor efficiently. Also, the chemical of legubicin, which uses doxorubicin and the substrate of legumain as key components can specifically target on tumors and increase the therapeutic effect. This review focuses on legumain to introduce its function in the development of tumor and the relative progression in the therapeutic strategy of tumors.