Therapeutic effects of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient
Therapeutic effects of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient
Abstract Calciphylaxis is a rare cutaneous vascular disease with clinical manifestations of intolerable pains, non-healing skin wounds, histologically characterized by calcification, fibrointimal hyperplasia, and thrombosis in microvessels. Currently, there are no approved guidelines for this disease. High prevalence of thrombophilias and hypercoagulable conditions in calciphylaxis patients have been recognized in recent years. Here, we report a case of uremic calciphylaxis patient whom was refractory to conventional treatments and then received a salvage strategy via human amnion-derived mesenchymal stem cell (hAMSC) intravenous combined with local application. In order to investigate the therapeutic mechanism of hMASCs from the novel perspective of hypercoagulability, coagulation-related indicators, wound status and quality of life were followed up. Improvement of hypercoagulable condition involving correction of platelet, D-dimer and plasminogen levels, skin regeneration and pain alleviation were revealed after hAMSC administration for one year. We propose that hypercoagulability is the therapeutic target of calciphylaxis patients which can be improved by hAMSC treatment.
Xu Xueqiang、Su Zhonglan、Lu Yan、Zhou Jing、Yang Guang、Lv Xiaolin、Bian Anning、Liu Jiayin、Liu Kang、Ning Song、Qin Lianju、Ma Xiang、Zeng Ming、Wang Ningning、Huang Yaoyu、Ye Xiaoxue、Yuan Yanggang、Wang Ling、Zhao Jing、Xing Changying、Wang Xiuqin、Cui Yugui、Liang Ningxia、Tang Shaowen、Wang Jing
Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalState Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalState Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalState Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalState Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalState Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Outpatient Treatment Clinic, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of International Cooperation, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalState Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalAcademy of Clinical and Translational Research, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province HospitalDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical UniversityDepartment of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital
临床医学皮肤病学、性病学基础医学
calciphylaxischronic kidney diseasehypercoagulabilitythrombophiliashuman amnion-derived mesenchymal stem cell
Xu Xueqiang,Su Zhonglan,Lu Yan,Zhou Jing,Yang Guang,Lv Xiaolin,Bian Anning,Liu Jiayin,Liu Kang,Ning Song,Qin Lianju,Ma Xiang,Zeng Ming,Wang Ningning,Huang Yaoyu,Ye Xiaoxue,Yuan Yanggang,Wang Ling,Zhao Jing,Xing Changying,Wang Xiuqin,Cui Yugui,Liang Ningxia,Tang Shaowen,Wang Jing.Therapeutic effects of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient[EB/OL].(2025-03-28)[2025-04-26].https://www.medrxiv.org/content/10.1101/2023.01.06.22283161.点此复制
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