脱氧核酶在DNA逻辑门上的应用

NA logic gate is important research interest of DNA nanotechnology in DNA computing. Connection communication between different DNA logic gates requires the construction of more basic logic elements. Deoxyribozyme is the main building element of DNA logic gates, which has the catalytic function of cleaving RNA and DNA molecules. Based on the DNA-cleaving catalytic property of the deoxyribozyme, two deoxyribozyme elements which can be used to construct the DNA gate were proposed. Though the design of logic gate elements and DNA sequences, two classes of DNA logic gates, NAND and NOR gate were constructed, which the input and output signals were both DNA strand. The results were verified by polyacrylamide gel electrophoresis (PAGE), which realized the NAND and NOR gate.