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冷冻干燥法制备碳纳米管/微管蛋白杂化材料

arbon Nanotubes/Microtubules Protein Hybrid Material was Synthesized by the Freeze Drying Mathod

中文摘要英文摘要

将单壁碳纳米管与微管蛋白结合,通过冷冻干燥法合成了碳纳米管/微管蛋白杂化材料,并与抗癌药物紫杉醇结合,从而得到碳纳米管/微管蛋白/紫杉醇复合材料。通过红外光谱(IR)、场发射、原子力显微镜(AFM)、拉曼光谱等手段对产物进行表征。结果表明:碳纳米管和微管蛋白紧密的结合在一起,并且微管蛋白的主要性能保持不变;由于微管蛋白的加入,也提高了碳纳米管的分散性;紫外吸收光谱表明紫杉醇成功结合到了上述杂化材料上;高效色谱测试表明1mg杂化材料可结合紫杉醇的含量为1.2μg,并探讨了碳纳米管作为紫杉醇的载体的可能性。

hrough the freeze drying mathod,single-walled carbon nanotube was combined with the microtubules protein and synthesized the hybrid material- carbon nanotubes/microtubules protein, which was combined with paclitaxel and then carbon nanotubes/microtubules protein/paclitaxel composite materials was composed finaly. Infrared spectrometry (IR), field emission, atomic force microscope (AFM), Raman spectroscopy had been used to characterize their structure and property. The reset indicated, carbon nanotubes and microtubules protein was linked together closely, and the main properties of microtubules protein was unchanged. Because of the microtubules protein, the dispersion of carbon nanotubes was also improved. The result of UV absorption spectra shows that the successful of the combination between paclitaxel and hybrid material. High-efficiency chromatographic tests show that the content of taxol that the hybrid material with 1 mg can be combined was 0.0012 mg, and carbon nanotubes used as the carrier of taxol became possible.

陈安良、陶菲、马培艳

药学生物科学现状、生物科学发展生物科学研究方法、生物科学研究技术

碳纳米管微管蛋白杂化材料紫杉醇

carbon nanotubesmicrotubules proteinthe hybrid materialtaxol

陈安良,陶菲,马培艳.冷冻干燥法制备碳纳米管/微管蛋白杂化材料[EB/OL].(2011-06-24)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/201106-429.点此复制

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